How Sermorelin impacts HGH and Testosterone Hormone Levels in Men
Sermorelin increases male testosterone levels. Men who take Sermorelin
boost their Growth Hormone levels AND Testosterone levels. The positive effects of increasing these hormones
includes a boost in sex drive and energy, improved BMI by increased lean muscle mass and reduced body fat. HGH complements Testosterone in stimulating male libido
and when men take Sermorelin, especially with either HCG or Testosterone, their sex drive improves. As natural HGH levels rise, other Sermorelin benefits are
increased ability to recover from workouts, more energy to engage in physical activity, improved vision and mental acuity.
Sermorelin Boosting Testosterone Study. Recent scientific studies show increases in men's Total Testosterone and FT / Free Testosterone by using GHRH agonist Sermorelin (SERM) along with other Growth Hormone (GH) Secretagogues such as GHRP-6 and GHRP-2.
As reported in the American Journal of Men's Health in its November 2017 issue, a recent study undertaken at the Laboratory for Male Reproductive Research and Testing at Baylor College of Medicine showed that Sermorelin (SERM) therapy increases serum Insulin-like growth factor 1 (IGF-1) to adequate natural levels. Since Insulin-like growth factor 1 (IGF-1) serves as a substitute marker to show levels of Growth Hormone (GH), the research study was undertaken to investigate a safe alternative mechanism for increasing the body’s own creation of Growth Hormone (GH), and the effect of GH-releasing peptides (GHRPs) or Sermorelin (SERM) therapy on Insulin-like Growth Factor 1 (IGF-1) levels.
The results of this study suggest that combination therapy may be beneficial in men and that it can contribute to increased Growth Hormone (GH) secretion, which contributes to significant increases in Testosterone and FT Free Testosterone.
Sermorelin for Men is an HGH Peptide Secretagogue. Several HGH Secretagogues, or substances that cause natural HGH to be secreted are available for sale. These include GH-releasing peptides (GHRPs): GHRP-2 and GHRP-6, and the GH-releasing hormone analog, Sermorelin (SERM - Sermorelin Acetate). In this study, the impact of the combination of these 3 secretagogues on serum hormone and Insulin-like Growth Factor 1 (IGF-1) levels in men on Testosterone (T) therapy was evaluated.
The study was conducted on men with hypogonadism, or Low Testosterone.
Men's Sermorelin Testosterone Study
Testosterone is the hormone that plays a key role in masculine growth and development during puberty. Male hypogonadism is a condition in which the body doesn't produce enough testosterone or has an impaired ability to produce sperm, or both. Free testosterone is a term that refers to the amount of testosterone in the bloodstream, usually tested in males with certain medical conditions. According to the American Association for Clinical Chemistry (AACC), free testosterone only accounts for 1-4 percent of the testosterone in a typical male's bloodstream.
Fourteen men with hypogonadism who were on testosterone therapy with baseline Insulin-like growth factor (IGF-1) levels of 200 ng/mL were treated with GHRP-6, GHRP-2, and Sermorelin (SERM) three times daily at a dose of 100 mcg of each compound delivered via subcutaneous injection. Sermorelin has a positive effect on a man's Free Testosterone level and
many hormone physicians are now prescribing Sermorelin Therapy for Men together with Testosterone Therapy - Testosterone Therapy for Men
Men's Sermorelin study demonstrates increased male sex hormone levels. With institutional review board (IRB) approval, a retrospective review of medical records was performed for 105 hypogonadal men on T therapy seeking gains in lean body mass and fat loss who were prescribed a combination of GHRP-6, GHRP-2, and Sermorelin (SERM). All patients were started on therapy between 2012 and 2015 at a dose of 100 mcg of each compound, injected subcutaneously three times daily. To be included in the study, compliance with treatment was required, which was assessed via frequency of prescription fills. Men refilling their Growth Hormone Secretagogue (GHS) prescriptions within 45 days for each month’s supply of drug were considered compliant. Men with baseline IGF-1 levels of greater than 200 ng/mL were included, and men with IGF-1 levels lower than 200 ng/mL excluded. Of the 105 initial men whose data were reviewed, 14 men met the above inclusion criteria and were included in the analysis.
Baseline serum hormone levels, including IGF-1, T, free T (FT), estradiol (E), luteinizing hormone (LH), and follicle-stimulating hormone (FSH), were determined prior to therapy initiation and at each follow-up appointment approximately every 3 to 4 months during treatment. All laboratory testing was performed by the Laboratory for Male Reproductive Research and Testing at Baylor College of Medicine. Testosterone serum levels increased in men taking Sermorelin injections.
Sermorelin impacts on Natural GH Growth Hormone on a Man's Body
Men who take Sermorelin can boost low HGH levels. Growth hormone (GH) increases lean body mass and reduces fat mass in adults, while it increases exercise tolerance and maximum oxygen uptake. Although there have been some safety concerns associated with external Growth hormone (GH) use, the study shows that these concerns may be mitigated by the use of Growth Hormone Secretagogues (GHSs), which stimulate internal Growth hormone (GH) production and maintain it within normal physiologic parameters. In addition, the most significant increases in natural Growth hormone (GH) release occur via synergistic action of GHRPs and GHRH acting at the Growth Hormone Secretagogues receptor (GHS-R) and GHRH receptor, respectively. GHRP/ Sermorelin (SERM) therapy increases serum Insulin-like Growth Factor 1 (IGF-1) levels with strict compliance to doses three times a day.
Why Sermorelin supplementation is effective in men. Men's normal serum Insulin-like Growth Factor 1 (IGF-1) levels decrease by age once a peak is reached during adolescence In one study of prostate cancer risk in men with a mean age of 59.3 years, an IGF-1 level >294 ng/mL, which is above the upper limit of the normal reference range in the population (233 ng/mL), has been associated with an increased risk of developing prostate cancer. Growth hormone Secretagogues (GHSs) can potentially provide similar benefits to those seen with the use of Growth hormone (GH) while avoiding the safety concerns associated with Growth hormone use, in part because Growth Hormone Secretagogues (GHSs) can reproduce natural Growth hormone secretion and limit Growth hormone and Insulin-like growth factor (IGF-1) production to the normal physiologic range, thereby not increasing the risk of developing prostate cancer.
In this study, significant increases in T/Testosterone and FT/Free Testosterone, levels were observed starting at 90 days of follow-up, and lasting into a 180-day and 270-day follow ups. The study results suggest that combination therapy may be beneficial in men with low Testosterone and that it can contribute to increased natural Growth hormone secretion. The study authors explain that future studies will be undertaken to encompass a larger patient population and a longer study duration in order to increase the study’s relevance.
Effects of Sermorelin on Male Growth Hormone & Testosterone Levels
Effects of Growth Hormone Secretagogue (GHS) treatment on Men's IGF-1 levels are positive.
Effects of Growth Hormone Secretagogues (GHS) Treatment on Male Testosterone Serum Hormone Levels are positive.
Total Testosterone base level 586.69 ng/dL increased to 1,060.3 ng/dL.
Free Testosterone base level 12.9 ng/dL increased to 23.6 ng/dL
IGF-1 Insulin-Like Growth factor-1 base level 159.5 ng/mL increased to 253.3 ng/mL
Read more about HGH Secretagogues GHRH Releasing Agents.
Men's HGH Therapy Alternative - Sermorelin
Sermorelin as an HGH Alternative and Growth Hormone Stimulation for Men with HGH Deficiency
Sermorelin Acetate is sometimes called GRF 1-29. Sermorelin is a growth hormone releasing hormone analogue.
It is a 29-amino acid polypeptide representing the 1-29 fragment from endogenous human growth hormone releasing hormone, and is thought to be the shortest fully functional fragment of GHRH.
is used as a test for measuring growth hormone secretion. Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues.
It stimulates the pituitary gland to naturally produce increased amounts of human growth hormone. Sermorelin Acetate
is a truncated analog of a growth hormone releasing factor (GRF 1-44) that is naturally produced by the brain to stimulate pituitary production of human growth hormone.
The increased volume of Human Growth Hormone
(HGH) produced by the pituitary gland causes an increase in the production of Insulin-Like Growth Factor-1 (IGF-1) by the liver and results in the excellent benefits of this hormone peptide.
Used extensively in HRT or Human Growth Hormone Replacement Therapy, and Anti-Aging Therapy often in conjunction with HGH injections. Purity: 99% (HPLC). 5mg per vial.
Buy sermorelin injections online: learn more about this natural HGH alternative, how sermorelin therapy works, its benefits and costs below.
Sermorelin Growth Hormone Releasing Peptide Treatment in Men Increases Blood Serum HGH Levels
Sermorelin Growth Hormone (GHRH) Therapy increases the volume of human growth hormone (HGH) secreted by the stimulated pituitary gland that is converted by the liver into IGF-1.
The increased amount of IGF-1 in the blood stream results an increase in metabolism and growth of new cells within the body's organs, muscles and bones.
This hormone peptide has been shown to increase lean muscle mass, reduce body fat, increase bone density, enhance the immune system, and strengthen the heart, as well as, other organs of the body.
Sermorelin is a very safe therapy for men. Since the increased volume of human growth hormone is produced by the body's pituitary gland, the body's endocrine system will not allow more growth hormone to be produced by the Sermorelin GH-RH stimulation of the pituitary than the body can safely process within the endocrine self-monitoring system.
Sermorelin is well tolerated by male patients. Many research studies have concluded that sermorelin is a well tolerated releasing analogue of GHRH which is also suitable for use as a provocative test of growth hormone deficiency.
Sermorelin is the New HGH Therapy for Men
Growth Hormone Releasing Peptide Treatment in Men Increases Serum Insulin-Like Growth Factor-1 Levels
Sermorelin Therapy for Men is so effective for the stimulation of men's natural human growth hormone (HGH), it is now being used alone or together with HGH injections to improve growth hormone treatment effects. HGH itself is a hormone that is known for having effects as an anti-aging therapy with clinical studies demonstrating injectable HGH could reverse biological age in 60-80 year olds by as much as 20-years.
The Daniel Rudman study reflected improvement in health factors measured including fat to muscle ratio, skin thickness and elasticity, spinal disc density, hair growth and thickness, hand grip strength, improved libido, energy and mood.
Both Sermorelin and HGH for men are available by prescription and must be used by injection to be effective.
Sermorelin Therapy and Male Aging
Aging is associated with reduced activities of the human growth hormone (HGH), insulin-like growth factor I (IGF-I), and male sex steroid, testosterone.
The decrease in these hormone activities results in a decreased lean body mass, reduced bone density and protein synthesis.
Sermorelin helps to stimulate growth hormone levels and may be prescribed for age-related male growth hormone insufficiency. After 6 months of administration of HGH sermorelin and male sex hormone using testosterone enanthate, cypionate or propionate to increase testosterone,
the result was a significant increase in IGF-I levels and positive effects on energy, muscle mass and body fat.
Sex steroid administration increases the levels of estrogen and testosterone in men and steps to mitigate aromatization need to be taken.
Sermorlein for Male Obesity. Semorelin Treatment for obese men has also been shown to be successful for fat reductions
and some age management physicians are helping treat Andropause weight gain symptoms with
Sermorelin Therapy for Weight Loss
to help manage rapid increases in body fat weight gain during male menopause (Andropause).
Sermorelin Acetate Injections for Men
Sermorelin, also known as GHRH, is a growth hormone-releasing hormone analogue used for HGH stimulation and as a diagnostic agent.
It is a 29-amino acid polypeptide representing the 1–29 fragment from endogenous human GHRH, and is thought to be the shortest fully functional fragment of GHRH.
Sermorelin Acetate has become a common HGH alternative for boosting endogenous growth hormone. It is used as a diagnostic agent to assess growth hormone secretion.
Sermorelin has a similar affect as HGH on sleep patterns and is also hypothesized to improve deep rapid eye movement sleep.
Once a day dosing pre-bedtime provides a restorative amount of growth hormone boost.
Multiple dosing or use of growth hormone somatropin will significantly raise IGF-1 levels which will lead to enhanced fat loss, muscle growth and injury repair.
Sermorelin Peptide Science
Sermorelin Acetate, also known as GRF 1-29, is a Growth Hormone Releasing Hormone (GHRH) produced by the brain that stimulates the production and release of Growth Hormone (GH). Sermorelin Acetate was first developed in the 70s, which is thought to be the shortest fully functional fragment of GHRH and has been used as a test for Growth Hormone secretion. It is often used extensively in Anti-aging Therapy along with Testosterone in men. Sermorelin Acetate affects a more primary source of failure in the GH neuroendocrine axis, has more physiological activity, and its use for adult hormone deficiency is not restricted. Compared to human Growth Hormone (hGH), Sermorelin Acetate is a growth hormone secretagogue, which means that it stimulates the pituitary gland to produce and secrete growth hormone. Also, Sermorelin Acetate and Modified GRF 1-29 contains 29 amino acids whereas hGH is a larger molecule containing 191 amino acids.
Low-dose Sermorelin GH administration increases protein synthesis, bone mineralization and libido in men, and co-administration of testosterone plus HGH enhances these effects in middle-aged and older men.
Using GHRH Peptides together with GHRP Peptides results in a synergistic release of human growth hormone from pituitary
providing a greater boost than either peptide HGH treatment on its own.
GHRH vs GHRP
What are the advantages of GHRP Peptides vs GHRH Peptides
While GHRH Growth Hormone-Releasing Hormone may be used alone as a growth hormone boosting treatment,
they are only effective when Somatostatin is low in the body. Somatostatin is the growth hormone inhibiting hormone.
Administering GHRH Peptides effectively. If you administer GHRH Peptide when Somatostatin is high and a growth hormone pulse is not occurring,
GHRH alone will add very little human growth hormone release.
If on the other hand, you administer a GHRH Peptide during a growth hormone pulse when Somatostatin is not active,
you will effectively add to your body's human growth hormone release.
GHRP injections are capable of boosting human growth hormone release all on their own.
So some endocrine physicians find that GHRP may be a more effective therapy for very low HGH.
GHRP treatment injections are able to raise GH levels with more consistency and predictability than GHRH Peptide injections.
This is true, regardless of Somatostatin presence or whether a growth hormone pulse is taking place.
Where can I buy Sermorelin for Men
Best Place to purchase Sermorelin Injections for Men near you.
The best place to buy Sermorelin Injections is a hormone treatment clinic as you can get the best price for Sermorelin, GHRP and HGH.
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Sermorelin Medical Research
What is Sermorelin Acetate?
Sermorelin Acetate is a GHRH (growth hormone–releasing hormone) peptide analogue. Its peptide sequence is comprised of 29 amino acids. This sequence is a portion of the endogenous human GHRH, and is currently considered to be the shortest synthetic peptide that possesses the full array of functional GHRH activity. Due to this fact, sermorelin is considered to be a growth hormone secretagogue.
Sermorelin has been used during research to stimulate the secretion of growth hormone from the adenohypophysis, also called the anterior pituitary gland. The anterior pituitary secretes trophic hormones. Sermorelin has also been used in research stimulation tests to assess for pituitary sufficiency in relation to the secretion of the growth hormone.
GHRH for Men
Growth hormone–releasing hormone
GHRH is 44 amino-acids polypeptide that stimulates the secretion of growth hormone from the adenohypophysis. It is also called somatocrinin or somatoliberin. It is produced in the cell bodies of periventricular arcuate neurons, and thereafter transported to the neurosecretory terminals of the neurons where they are released. The arcuate neurons do form part of the hypothalamo-hypophyseal portal system. Their release from the neurosecretory terminals occur in a pulsatile fashion and it thus follows that growth hormone (GH) release also occurs in a corresponding pulsatile fashion. GHRH binds to a secretin-type G-protein coupled serpentine receptor called the GHRH-receptor (GHRHR). Binding causes the receptor to activate both the cAMP (cyclic Adenosine Monophosphate)-dependent pathway and the phospholipase C (PLC) pathway. The terminal downstream actions of the cAMP-dependent pathway do upregulate the transcription of both the GH and GHRHR genes thereby providing a positive feedback loop that amplifies the production of GH. The GH produced is thereafter packaged in secretory vesicles. The downstream actions of the PLC pathway results in both Na+-voltage-dependent and Ca2+-dependent fusion of the secretory vesicles with the plasma membrane thereby releasing GH into the bloodstream.
The actions of HGH ensure an optimal well-regulated post-natal growth. Human Growth Hormone also promotes efficient energy metabolism. Studies have also shown that GHRH directly promotes slow wave NREM (non-rapid eye movement) sleep, and thus GHRH insufficiency causes a reduction in the amount and intensity of slow wave NREM sleep which results in either insomnia or dysomnia (sleep disorders that causes sleep to lose its restorative capacity). Studies have also shown that GHRH inhibits the actions of somatostatin. Somatostatin is a polypeptide hormone that inhibits GH secretion from the adenohypophysis. Both GHRH and somatostatin are produced in the same neuron but they are released in alternation to each other thereby resulting in the pulsatile release of GH from the neuron.
Recent research has also shown that GHRH is also produced outside the hypothalamus by pancreatic cells, gastrointestinal tract epithelial cells and in some neoplastic cells. Clinical studies have also shown that the actions of Sermorelin are similar to the GHRH actions. Thus, Sermorelin has been used to diagnose deficiencies in GH secretions. Also, Sermorelin has been investigated for its therapeutic properties as the studies discussed below show.
HGH Peptide Research Results
Sermorelin Clinical Studies - HGH Alternative
Sermorelin Therapy is the best HGH Alternative. Clinical research shows that sermorelin can be used clinically to promote growth and manage GHRH deficiency.
Sermorelin and treating growth hormone (GH) deficiency. In 1999, a study entitled Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency was authored by Aitabh Prakash and Karen Goa and published in the journal Biodrugs. The aim of this study was to investigate whether sermorelin injection stimulates GH secretion from the adenohypophysis. The subjects of this study included adults and pre-pubertal children (both normal and those suffering from GH deficiency). The subjects were randomly divided into two groups with one group receiving intravenous sermorelin injection and the other group receiving subcutaneous sermorelin injection.
The results obtained from both groups showed that Sermorelin was able to rapidly diagnose GH insufficiency in children affected by GH deficiency.
The results also revealed that subcutaneous sermorelin injection did cause a significant increase in height in children suffering from idiopathic GH deficiency, and that this acceleration in growth rate could be maintained consistently for 36 months. Likewise, the results also revealed that both Sermorelin administrations were well tolerated with the only observable adverse effects being injection-site pain and transient facial flushing.
In summary, the findings of this study show that sermorelin stimulates GH secretion from the adenohypophysis.
Intravenous sermorelin can be used to diagnose some cases of GH deficiency, and subcutaneous sermorelin can be used to manage GH insufficiency.
Using Sermorelin with GHRP
Combination Sermorelin Therapy with GHRP-6, GHRP-2,
and SERM increases male serum IGF-1 levels. This positive effect is observed with
strict compliance to 3 times daily Sermorelin dosing. Increases in serum IGF-1
while on treatment approaches the upper limits of the laboratory
reference range for insulin-like growth factor-1 (250 ng/ml).
Clinical results suggest that combination therapy
with GHRP-6, GHRP-2, and SERM may be beneficial in to increasing HGH and IGF-1 levels.
Sermorelin and growth acceleration in a chronic disease state.
In 1996, Pasqualini et al conducted a study that was published under the title Growth acceleration in children with chronic renal failure treated with growth-hormone-releasing hormone (GHRH) in the journal Medicina. The subjects involved in this study were 9 children aged between 1 to 14 years old. They all suffered from chronic renal failure (CRF). The aim of this study was to investigate whether subcutaneous Sermorelin causes growth increase in children ailing from CRF. The subjects were categorized into 3 groups, the first group comprised of 3 children on conservative management, the second group comprised of 3 children on dialysis and the last group comprised 3 children who had undergone renal transplantation. Each of the three groups was administered with subcutaneous Sermorelin acetate (Geref ®) for a period of 3-6 months.
The results showed that the mean serum creatinine and urea levels remained stable in all the subjects except for two children on conservative management who showed an increase in their serum creatinine levels.
The results also revealed that the rate of height increase in 5 of the subjects averaged about 4.2cm/year.
In summary, the findings of this study show that sermorelin does increase the rate of growth in GH-responsive CRF children.
In conclusion, the above two studies show that Sermorelin can be used in research to diagnose cases of GH deficiency, stimulates GH secretion from the adenohypophysis, manage GH insufficiency and increase the rate of growth in GH-responsive CRF children.
The Sermorelin Acetate Peptide and HGH
Sermorelin Acetate, which shares similar structure to CJC-1295, is a bio-identical synthetic hormone that is extremely effective in increasing the amount of HGH. Human Growth Hormone is a hormone released by the body that controls the reproduction and growth of the cells and each of the organs in the body. At a young age, the body's HGH production is most active while the growth rate is at its highest point. After the age of 30, for every decade of life, there is a 14% reduction in HGH production . By the age of 40, HGH production is about 40 percent of what it was at the age of 20. With the further development of Growth Hormone Releasing Factors (GHRF), such as Modified GRF 1-29, HGH production may possibly begin again by stimulating the pituitary gland.
Sermorelin Acetate and Related Medical Research
Since 1980, scientists have been studying GHRH for many years. Dr. Daniel Rudman who pioneered the famous HGH study, was testing Sermorelin as a tool for anti-aging processes, and Dr. William Wehrenberg was looking at different peptides and particularly GHRH to identify which part of it is needed for pituitary gland stimulating response. His results after eliminating single amino acids showed that 29-acid-chains were held responsible for pituitary stimulation. Many research studies have concluded that Sermorelin is a well tolerated analogue of GHRH. As a result, this is suitable for use as a provocative test of growth hormone deficiency (Prakash and Goa 1999). In 1999, both researchers, Goa and Prakash checked Sermorelin Growth Hormone as provocative tasting method for deficiency of endogenous G-hormone. Sermorelin therapy increased the volume of hormone secreted by the stimulated pituitary gland, which is later converted by the liver into IGF-1. The increased amount of IGF-1 in the blood stream leads to many benefits from the use of Sermorelin: increasing metabolism and growth of new cells within the body’s organs and bones.
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